Meningiomas: From Pathology to Clinics

This book aims to explore the correlation between pathology and molecular biology with the clinical and diagnostic features, management, and outcome of meningiomas. With its unique structure consisting of 6 parts and 22 chapters, it provides a comprehensive analysis of this topic. Each chapter delves into the pathological features, emphasizing their clinical implications, making this book distinct from others in its field.

Several topics discussed in this book are not found in other texts. These include the hormone-related clinical factors, the clinical impact of the 2021 WHO Classification of tumors of the CNS, the clinical and prognostic role of hormone-receptor expression, the pattern of dural invasion, the brain-tumor interface and brain invasion, and the radiomics.

Part I serves as an introduction, focusing on the most recent research on the origin and growth of meningiomas. Part II explores the various aspects and the correlation of meningioma occurrence within the general population. Part III centers around the clinical impact of macroscopic, histological, and biomolecular features of meningiomas. Part IV is dedicated to imaging diagnosis, including a chapter on radiomics, a novel and sophisticated imaging technique not covered in other texts.

Part V examines the impact of pathology on the management of meningiomas, encompassing modern radiotherapeutic and biomolecular targeted therapies. Finally, Part VI delves into meningioma recurrence, with a unique chapter on the topography of recurrences, a topic not extensively discussed in other books.

The primary audience for this book includes neurooncologists, neurosurgeons, radiotherapists, neuroradiologists, pathologists with a focus on molecular biology, as well as neurologists and geneticists. It serves as a valuable resource for professionals in these fields, providing in-depth insights into the correlation between pathology, molecular biology, and the clinical aspects of meningiomas.

Francesco Maiuri is Emeritus Professor of Neurosurgery, University of Naples "Federico II". He focused his scientific and surgical activity on the diagnosis and management of the tumors of the nervous system, mainly meningiomas, and to the skull base and cranioorbital pathologies. He was president of the Italian Association of Neuro-Oncology (AINO). He is author of about 300 scientific publications, mainly in international journals with high impact factor and editor of several neurosurgical books.

Marialaura Del Basso De Caro is Professor of Pathological Anatomy at University of Naples Federico II Department of Advanced Biomedical Sciences. She is the author of more than 100 Communications to National and International Congresses, and of at least 170 scientific papers published in national and international journals, indexed on Index/Medicus/Journal Citation Index. She also contributed to 5 books with chapters mainly focused on the process of neoplastic progression and the search for new molecular markers prognostic and/ or response to therapy after surgery for tumours of the Central Nervous System, tumors of the pituitary gland and neuroendocrine tumors. She was member of the European Multidisciplinary Group for Neuroendocrine Tumours (ENETS) as well as of the Naples Multidisciplinary Group of Central Nervous System tumors.