MODEL ORGANISMS IN DRUG DISCOVERY
CARROLL
Sold by Speedyhen, Hertfordshire, United Kingdom
AbeBooks Seller since 26 November 2009
New - Hardcover
Condition: New
Ships from United Kingdom to U.S.A.
Quantity: 1 available
Add to basketSold by Speedyhen, Hertfordshire, United Kingdom
AbeBooks Seller since 26 November 2009
Condition: New
Quantity: 1 available
Add to basketFeed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems.
Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future.
Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future.
This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.
Pamela M. Carroll is the editor of Model Organisms in Drug Discovery, published by Wiley.
Kevin Fitzgerald is the editor of Model Organisms in Drug Discovery, published by Wiley.
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