MIPs and Their Roles in the Exchange of Metalloids (Hardcover)

Language: English

Published by Springer-Verlag New York Inc., New York, NY, 2010

1441963146 / 9781441963147

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Hardcover. Sixteen years have passed since human aquaporin-1 (AQP1) was discovered as the first water channel, facilitating trans-membrane water fluxes. Subsequent years of research showed that the water channel AQP1 was only the tip of an iceberg; the iceberg itself being the ubiquitous super family of membrane intrinsic proteins (MIPs) that facilitate trans-membrane transport of water and an increasing number of small, water-soluble and uncharged compounds. Here we introduce you to the superfamily of MIPs and provide a summary about our gradually refined understanding of the phylogenetic relationship of its members. This volume is dedicated to the metalloids, a recently discovered group of substrates for a number of specific MIPs in a diverse spectrum of organisms. Particular focus is given to the essential boron, the beneficial silicon and the highly toxic arsenic. The respective MIP isoforms that facilitate the transport of these metalloids include members from several clades of the phylogenetic tree, suggesting that metalloid transport is an ancient function within this family of channel proteins. Among all the various substrates that have been shown to be transported by MIPs, metalloids take an outstanding position. While water transport seems to be a common function of many MIPs, single isoforms in plants have been identified as being crucially important for the uptake of boric acid as well as silicic acid. Here, the function seems not to be redundant, as mutations in those genes render plants deficient in boron and silicon, respectively. The respective MIP isoforms that facilitate the transport of these metalloids include members from several clades of the phylogenetic tree, suggesting that metalloid transport is an ancient function within this family of channel proteins. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Seller Inventory # 9781441963147

Title
MIPs and Their Roles in the Exchange of Metalloids (Hardcover)
Author
Thomas P. Jahn
Publisher
Springer-Verlag New York Inc., New York, NY
Publication year
2010
Condition
new
Binding
Hardcover
Language
English
ISBN 10
1441963146
ISBN 13
9781441963147

Grand Eagle Retail

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