Lysophosphatidic Acid Induction Of Tissue Factor Gene Expression

Language: English

Published by LAP LAMBERT Academic Publishing Aug 2010, 2010

3838381378 / 9783838381374

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This item is printed on demand - Print on Demand Titel. Neuware -LPA is a component of oxidized low density lipoproteins (oxLDL) which has been shown to accumulate in human atherosclerotic plaques. Tissue factor (TF) is the principal initiator of blood coagulation. Tissue factor upregulation in atherosclerotic plaque can lead to undesirable vascular thrombosis. The generation of reactive oxygen species (ROS), which act as signaling molecules in the vascular system, is enhanced in response to injury and has been associated with a procoagulant state and the progression of atherosclerotic disease. Oxidative stress might contribute to the increased expression of pro atherosclerotic genes at sites of vascular injury, including TF. Little is known about the regulation of TF by LPA in smooth muscle cells (SMC) which is a major player in the process of atherosclerosis. Data generated by this study demonstrate that LPA markedly induces TF expression in rat aorta smooth muscle cells (RASMCs) and human aorta smooth muscle cells (HASMCs). The signaling pathways involved are multiple.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch.…

Seller Inventory # 9783838381374

Title
Lysophosphatidic Acid Induction Of Tissue Factor Gene Expression
Author
Essam Laag
Publisher
LAP LAMBERT Academic Publishing Aug 2010
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3838381378
ISBN 13
9783838381374
Item weight
161 grams
Dimensions
220x150x6 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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