The Link Between Inflammation and Cancer : Wounds that do not heal
Language: English
Published by Springer, 2010
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 145.46
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Add to basketItem description from seller
Druck auf Anfrage Neuware - Printed after ordering - A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment. …
Seller Inventory # 9781441938817
- Title
- The Link Between Inflammation and Cancer : Wounds that do not heal
- Author
- Angus G. Dalgleish
- Publisher
- Springer
- Publication year
- 2010
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 1441938818
- ISBN 13
- 9781441938817
- Item weight
- 411 grams
- Dimensions
- 235x155x15 mm
- Series
- Book 51 of 180: Cancer Treatment and Research
"Synopsis" may belong to another edition of this title.
From the Back Cover
The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and many types of cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book.
Series Editor Cover Comments:
"Inflammation is a known risk factor for a number of cancers. In this text, experts discuss the pathophysiology and molecular alterations that link these two processes. Potential therapeutics and preventive strategies are discussed."
Steven T. Rosen, M.D.
Series Editor
"About the title" may belong to another edition of this title.
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