Alcohol abuse is associated with psycho-somatic health and social problems. It leads to multi-organ, especially cardiovascular system, alimentary tract, liver, pancreas and immunologic system dysfunction. Therefore withdrawal and anti-relapse therapy should be undoubtedly undertaken in every case. Nevertheless our knowledge about alcohol withdrawal consequences is insufficient. The main purpose of the authors' investigation was to determine the metabolic, endocrine, haemostatic and immunologic changes during six-month long abstinence period. They studied the abstinence effect on exercise capacity and autonomic nervous system activity estimated by heart rate variability analysis. Their research concerned also changes in upper digestive tract macroscopic and microscopic appearance and its motility, liver function, pro- anti- oxidative balance parameters level, cytokine TNF- alpha and nitric oxide (NO) metabolites plasma concentration. The authors estimated inter-relationships between studied parameters, what seems to be very important in complete analysis. Within six-months long abstinence period pro-atherogenic metabolic changes expressed by decreased HDL and increased LDL- cholesterol plasma concentration occurred. These unfavourable changes were less expressed in patients treated with naltrexone. In the early abstinence period indirect markers of platelets activation were determined. The highest level of fibrinogen, thrombomodulin, antithrombin, markers of trombinogenesis activation in vivo (thrombin- antithrombin, TAT complexes), tissue type plasminogen activator antigen (t-PA:Ag), antigen of plasminogen activator inhibitor type 1 (PAI-1:Ag), markers of fibrinolysis activation in vivo, such as D-dimers, plasmin- alpha2- antiplasmin (PAP) complexes was also observed. Mentioned changes were expressed in patients with determinable TNF-alpha plasma level. Abstinence improved effort capacity, positively changed autonomic nervous system activity via vagal nerve influence on heart rate variability. The last finding was also affected by TNF-alpha level. No significant changes appeared in alimentary tract function, estimated by esophageal and gastric pH-metry, esophageal manometry and abdominal ultrasonography, whereas some changes were observed in endoscopic examinations and influence of patients mental status on investigated parameters became noticeable. Favourable effect on liver function tests was affected by pituitary-thyroid and pituitary-gonadal axes hormones, cytokine TNF-alpha, nutrition status, Helicobacter pylori infection and gastric acidity. Some of studied parameters, such as mean platelets volume and nitric oxide metabolites plasma level may be used as new, valuable markers of alcohol abuse. Alcohol withdrawal and early abstinence is a dynamic period with potentially harmful health consequences, especially in cardiovascular system. This suggests the need of multicentre studies to estimate clinical importance of found changes and cost- benefits analysis of selected interventions.

"Synopsis" may belong to another edition of this title.

moluna

Greven, Germany

5-star seller

AbeBooks seller since July 9, 2020

Shipping rates from Germany to U.S.A.

Item	13 to 40 business days	13 to 40 business days
First item	£ 41.01	£ 41.01

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.

Payment methods

Bank Wire Transfer
Check
Paypal

Store description

Online Handel nur mit Neubüchern

Seller's business information

Moluna GmbH

Engberdingdamm 27
Greven, Germany 48268

Contact sellerView this seller's itemsView seller's storefront

Terms of sale

About Us

Legal website operator identification:

Moluna GmbH
Represented by the general manager Helge Blischke
Engberdingdamm 27
48268 Greven
Germany
Telephone: 02571/5698933
Telefax: 02571/5698930
E-Mail: abe@moluna.de
VAT No.: DE296281834
listed in the commercial register of the local court Steinfurt
Commercial register number - Part B of the commercial register - 10553

We are a member of the initiative „FairCommerce“ since 24.07.2015.
For more information, see: www.haendlerbund.de/faircommerce.

Right of withdrawal

If you are a consumer you can withdraw from the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.

Information regarding the right of withdrawal

Statutory right to withdraw

You have the right to withdraw from this contract within 14 days without giving any reason.

The withdrawal period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the last good or the last lot or piece.

To exercise the right of withdrawal, electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". We will communicate to you an acknowledgement of receipt of such a withdrawal on a durable medium (e.g. by e-mail) without delay.

To meet the withdrawal deadline, it is sufficient for you to send your communication concerning your exercise of the right of withdrawal before the withdrawal period has expired.

Effects of withdrawal

If you withdraw from this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).

We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.

We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to withdraw from this contract.

We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.

We may withhold reimbursement until we have received the goods back, or you have supplied evidence of having sent back the goods, whichever is the earliest.

You shall send back the goods or hand them over to moluna, Greven, Germany, without undue delay and in any event not later than 14 days from the day on which you communicate your withdrawal from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.

Exceptions to the right of withdrawal

The right of withdrawal does not apply to:

The delivery of newspapers, journals or magazines with the exception of subscription contracts; and
The supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not withdraw once delivery had started.

Klopocka, M: Systemic & Metabolic Changes Observed in Alcoho

Item description from seller

Bibliographic details

Synopsis