Isolation and Molecular Characterization of Circulating Tumor Cells
Language: English
Published by Palgrave Macmillan, 2018
Series: Book 295 of 544 - Advances in Experimental Medicine and Biology
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 168.22
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches -e.g., multiplexed QPCR, microarray, and next generation sequencing analyses- to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology.…
Seller Inventory # 9783319857879
- Title
- Isolation and Molecular Characterization of Circulating Tumor Cells
- Author
- John W. Park
- Publisher
- Palgrave Macmillan
- Publication year
- 2018
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3319857878
- ISBN 13
- 9783319857879
- Item weight
- 487 grams
- Dimensions
- 235x155x18 mm
- Series
- Book 295 of 544: Advances in Experimental Medicine and Biology
"Synopsis" may belong to another edition of this title.
From the Back Cover
The past decade has seen remarkable progress in elucidating the clinical relevance of circulating tumor cells (CTCs). Evidence from numerous clinical studies has unequivocally demonstrated the importance of CTCs as harbingers of poor outcome. Despite these advances, the molecular nature of CTCs remains elusive. This is in part due to the difficulty in isolating pure CTCs away from blood cells.
Recent advancements in rare-cell technology have provided solutions to the once daunting task of isolating extremely rare CTCs in the blood of cancer patients. This book presents different novel approaches for detection and purification of CTCs. In addition, the readers are introduced to new technologies for molecular profiling of CTCs, including techniques to overcome limitations posed by the paucity of cells and the biomolecules available for downstream molecular analysis.
This book is particularly relevant to scientists and academicians who are interested in the field of CTC research. It provides an overview of the recent technological advances in CTC isolation and profiling. This work also includes discussions on pertinent issues regarding the biology of CTCs, and their potential utility as liquid biopsy for personalized medicine. We hope that this book stimulate further research and help advance our understanding of the molecular biology of CTCs.
"About the title" may belong to another edition of this title.
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