Introduction to Cell Mechanics and Mechanobiology

This comprehensive second edition provides a pedagogical introduction to cell mechanics and mechanobiology. featuring quantitative descriptions of key concepts and solved examples throughout. The textbook demonstrates how understanding cellular responses to mechanical forces allows us to predict cell behavior and functionality in various environments.

Introduction to Cell Mechanics and Mechanobiology, Second Edition, asks key questions about the quantitative concepts that comprise this interdisciplinary field. The authors provide clear explanations of complex mechanobiological phenomena, from single-molecule mechanics to whole-cell responses. This book covers essential topics, including cellular polymers, cytoskeleton networks, membrane mechanics, and mechanotransduction. There are primer chapters on solid mechanics, fluid mechanics, statistical mechanics, and cell biology to ensure accessibility for students from diverse backgrounds.

Designed for advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering, users will appreciate complete derivations of relevant equations, practical laboratory applications, and comprehensive coverage of nuclear biomechanics. The twelve detailed chapters provide a complete framework for understanding the technical and biological aspects of cellular mechanics. Thus, this book is an invaluable resource for mastering the quantitative principles of mechanobiology.

Christopher R. Jacobs (1965–2018) was a professor of Biomedical Engineering at Columbia University, where he served as the director of the Cell and Molecular Biomechanics Lab. A recognized leader in the field, Dr. Jacobs made seminal contributions to the understanding of bone cellular mechanotransduction and computational biomechanics, conducting research that aided in the development of new therapies for age-related bone loss and osteoporosis. His dedication to bridging the disciplines of mechanics and biology continues to influence the field.

Hayden Huang is a biomedical engineer by training. He currently works on issues at the intersection of health care and technology to help inform policymakers. Previously, he was a faculty member in the Department of Biomedical Engineering at Columbia University, where his research investigated cell mechanics and cardiovascular physiology. Dr. Huang was a key architect of the first edition of Introduction to Cell Mechanics and Mechanobiology, drawing on his experience teaching the subject to a wide range of students from engineering to biological backgrounds.

Mohammad R. Kaazempur Mofrad is a professor of Bioengineering and Mechanical Engineering at UC Berkeley, where he leads a multidisciplinary research program at the interface of biomechanics, mechanobiology, artificial intelligence (AI), and computational biology. His laboratory investigates how physical forces shape biological structure and function across molecular, cellular, and multicellular scales, while also developing computational tools and AI-driven approaches to advance human health.