Integrins in Health and Disease : Key Effectors of Cell-matrix and Cell-cell Interactions
Language: English
Published by Springer, 2023
- Hardcover
- New
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- Title
- Integrins in Health and Disease : Key Effectors of Cell-matrix and Cell-cell Interactions
- Author
- Gullberg, Donald (EDT); Eble, Johannes (EDT)
- Publisher
- Springer
- Publication year
- 2023
- Condition
- New
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 3031237803
- ISBN 13
- 9783031237805
Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis.
This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the bookdiscusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion.
Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative.
The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
"Synopsis" may belong to another edition of this title.
About the Author
After having studied biochemistry at the University of Tübingen, Johannes A. Eblegained an intense training on extracellular matrix and collagen-binding integrins during his doctorate thesis at the Max Planck-Institute of Biochemistry in Martinsried close to Munich. In 1994, he gained his doctorate degree from the Ludwig Maximilians-University, Munich, under the Prof. Dr. Klaus Kühn’s supervision. During 1995-1998, he intensified his knowledge of integrins under Prof. Martin Hemler’s supervision at the Dana Faber-Cancer Institute of Harvard Medical School in Boston, where he developed the technique of recombinant expression of soluble integrins, especially of the laminin-332-binding ITGA3 integrin. After his return to Germany, he habilitated at the University of Münster in 2004. In 2008, he was appointed to a professorship of vascular matrix biology at the University of Frankfurt within the Excellence Cluster Cardio-Pulmonary System. Since 2014, he heads the Institute of Physiological Chemistry and Pathobiochemistry of the University of Münster. Although his scientific focus still pivots around integrins, his view on cell adhesion and migration has widened to integrin agonists and antagonists, the former being recombinant integrin-binding mini-collagen and mini-laminin-332, the latter being integrin-blocking snake venom toxins. Moreover, redox regulation of integrins and cell-matrix contacts is also included in his research portfolio.
"About the title" may belong to another edition of this title.
GreatBookPrices
Columbia, MD, U.S.A.
AbeBooks seller since April 6, 2009
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