This book provides an overview of the history of integrative bioinformatics and the actual situation and the relevant tools. Subjects cover the essential topics, basic introductions, and latest developments; biological data integration and manipulation; modeling and simulation of networks; as well as a number of applications of integrative bioinformatics. It aims to provide basic introduction of biological information systems and guidance for the computational analysis of systems biology. This book covers a range of issues and methods that unveil a multitude of omics data integration and relevance that integrative bioinformatics has today. It contains a unique compilation of invited and selected articles from the Journal of Integrative Bioinformatics (JIB) and annual meetings of the International Symposium on Integrative Bioinformatics.

About the Author

Ming Chen is the Director of the Bioinformatics Laboratory at the College of Life Sciences, Zhejiang University (China). He received his PhD in Bioinformatics from Bielefeld University (Germany). His group research work covers bioinformatics, systems biology, non-coding RNA transcriptomics, and precision medicine. He published over 200 papers on peer-viewed journals. He is the President of the Bioinformatics Society of Zhejiang Province, China; Deputy director of Chinese Society for "Modeling and Simulation of Biological Systems", Committee executive member of Chinese Society for "Computational Systems Biology" and Committee member of Chinese Societies for "Functional Genomics & Systems Biology", "Biomedical Information Technology" and "Biophysics (Bioinformatics) ".

Ralf Hofest�dt studied Computer Science and Bioinformatics at the University of Bonn. He finished his PhD in Computer Science (University Bonn) and his Habilitation (Applied Computer Science and Bioinformatics) at the University of Koblenz. He was Professor for Applied Computer Science at the University of Magdeburg. Now he is Professor for Bioinformatics and Medical Informatics at the University Bielefeld. He launched the Journal of Integrative Bioinformatics in early 2000’s. The research topics of the department concentrate on biomedical data management, modeling and simulation of metabolic processes, parallel computing and multimedia implementation of virtual scenarios.

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