Integration of Pharmaceutical Discovery and Development

Language: English

Published by Springer US, Springer Aug 1998, 1998

0306457431 / 9780306457432

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This item is printed on demand - Print on Demand Titel. Neuware -In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 648 pp. Englisch.

Seller Inventory # 9780306457432

Title
Integration of Pharmaceutical Discovery and Development
Author
Ronald T. Borchardt
Publisher
Springer US, Springer Aug 1998
Publication year
1998
Condition
Neu
Binding
Buch
Language
English
ISBN 10
0306457431
ISBN 13
9780306457432
Item weight
1,127 grams
Dimensions
241x160x40 mm

buchversandmimpf2000

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