Insights into Receptor Function and New Drug Development Targets (Research and Perspectives in Endocrine Interactions)
Language: English
Published by Springer, 2006
Series: Book 5 of 15 - Research and Perspectives in Endocrine Interactions
- Hardcover
- Used
Condition: Used - Fine
Current price: £ 33.16
Quantity: 1 available
Add to basketItem description from seller
Ancien livre de bibliothèque avec équipements. Edition 2006. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 2006. Ammareal gives back up to 15% of this item's net price to charity organizations.
Seller Inventory # H-630-629
- Title
- Insights into Receptor Function and New Drug Development Targets (Research and Perspectives in Endocrine Interactions)
- Publisher
- Springer
- Publication year
- 2006
- Condition
- Très bon
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 3540344462
- ISBN 13
- 9783540344469
- Series
- Book 5 of 15: Research and Perspectives in Endocrine Interactions
We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes with pharmacoperones. Ion channels, regulators of G-protein signaling and enzymes engaged in regulation, now present opportunities for drug development.
The state of our art also benefits by the availability of superior tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.
"Synopsis" may belong to another edition of this title.
From the Back Cover
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function.
The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.
The completion of the human genome has identified a new source of therapeutic targets: "orphan receptors" with unknown functions and yet-to-be discovered ligands. Some orphans have now been identified as ghrelin, nociceptin, apelin, and urocortin. This finding, along with important technologies to develop ligands with desirable characteristics, including peptidomimetics is likely to further accelerate interest in this area.
"About the title" may belong to another edition of this title.
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English below. Ammareal est une librairie professionnelle spécialisée dans le livre d’occasion. Nous expédions partout dans le monde. Nous avons plus de 250 000 ouvrages en stock dont un grand nombre de livres techniques et académiques. Nous reversons jusqu’à 15% du prix de vente de chaque livre à des organisations caritatives, des bibliothèques et des associations luttant contre l’illettrisme. Ce que nous ne vendons pas nous le donnons, ce que nous ne donnons pas nous le recyclons. Ammareal is a professional bookseller speciliazed in used books. We ship worldwide. We have more than 250 000 books in stock, including a large number of technical and university-level books. We give back up to 15% of the price of each book to charities, libraries and organizations fighting in favor of literacy. What we do not sell, we give, what we do not give we recycle.…
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Ammareal is a professional bookseller speciliazed in used books. We ship worldwide. We have more than 250 000 books in stock, including a large number of technical and university-level books. We give back up to 15% of the price of each book to charities, libraries and organizations fighting in favor of literacy. What we do not sell, we give, what we do not give we recycle.
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