Impact of Folate Absorption and Transport for Nutrition and Drug Targeting

Language: English

Published by VDM Verlag Dr. Müller, VDM Verlag Dr. Müller E.K., 2008

363901068X / 9783639010688

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Softcover

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nach der Bestellung gedruckt Neuware - Printed after ordering - Food-drug interactions play an important role in the alteration of the pharmacokinetics as well as pharmacodynamics of drugs in vivo. The interaction of folic acid and tea was observed at the level of cellular uptake using Caco-2 cell monolayers. Remarkably, the clinical study with healthy human volunteers confirmed the interaction between tea and folic acid in vivo leading to lower bioavailabilities of folic acid. This outcome addresses the clinical consequences of folate deficiency caused by high intakes of tea.Folates have been employed as targeting moieties to tumor cells. Folic acid has a high affinity to folate receptors which are overexpressed in tumor cells. Therefore internalization of folic acid conjugated drugs or drug delivery systems are readily carried out via those receptors. A novel micelle platform consisting of amphiphilic DNA block copolymers was introduced for the first time for chemotherapeutic drug delivery, allowing the combinatorial testing of the drug carrier system. Folic acid conjugated nanoparticles act as a potential chemotherapeutic drug delivery system in in vitro assays.…

Title
Impact of Folate Absorption and Transport for Nutrition and Drug Targeting
Author
N. Ceren Alemdaroglu
Publisher
VDM Verlag Dr. Müller, VDM Verlag Dr. Müller E.K.
Publication year
2008
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
363901068X
ISBN 13
9783639010688
Item weight
356 grams
Dimensions
220x150x14 mm

AHA-BUCH GmbH

Einbeck, Germany

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