Impact of Amphotericin-B on the Nitric Oxide Pathway in Rats

Language: English

Published by LAP LAMBERT Academic Publishing Jan 2013, 2013

3659311162 / 9783659311161

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This item is printed on demand - it takes 3-4 days longer - Neuware -The therapeutic use of polyene antibiotic amphotericin B is known to produce a number of toxic side effects such as fever, chills, nausea, vomiting, headache and renal dysfunction with associated anoxia, hypoxalamine, nephrotoxicity including myocardial toxicity. Amphotericin B associated cellular toxicity in part has been shown to be due to lipid peroxide damage in many experimental studies. Recognition of nitric oxide (NO) as the chemical entity of endothelium-derived factor (EDRF) has renewed the interest of the scientific community in the last decade and NO was labeled as Molecule of the year 1992 and further as Molecule of the Millennium In the cardiovascular system NO exert negative inotropic and negative chronotropic effect on cardiac muscle cells, it regulates beat-to-beat regulation of cardiac function. NO regulates blood flow and pressure and potent inhibitor of platelet aggression. In view of the toxic side effects exerted by Amphotericin B and physiological roles assigned to NO, present study examined the in vivo effect of selected doses of Amphotericin B on NO pathway parameters in animal Albino rat model. 156 pp. Englisch.…

Seller Inventory # 9783659311161

Title
Impact of Amphotericin-B on the Nitric Oxide Pathway in Rats
Author
Chandragiri Ashoka Kumar
Publisher
LAP LAMBERT Academic Publishing Jan 2013
Publication year
2013
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659311162
ISBN 13
9783659311161
Item weight
250 grams
Dimensions
220x150x10 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

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