IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN ORAL CANCER

Language: English

Published by LAP LAMBERT Academic Publishing Sep 2010, 2010

3843352178 / 9783843352178

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This item is printed on demand - Print on Demand Titel. Neuware -The expression of simple epithelial cytokeratins 8 and 18 is normally seen in the embryonic cells and lost in adult squamous epithelium. CK 8 and 18 play a role in tumor progression and metastatic potential as these are expressed only in the poorly differentiated and not in well differentiated squamous cell carcinomas. It appears that increased expression of the embryonic or simple epithelial cytokeratins 8 and 18 in some way changes the phenotypic characteristics of stratified epithelial cells, resulting in malignant transformation. Presence of Cytokeratin 8 and 18 in poorly differentiated foci of Oral squamous cell carcinoma even in the absence of metastasis could indicate a poor prognosis in these patients. However they are of functional importance in malignancy of keratinocytes and could be related to tumor invasion and/or to changes in epithelial mesenchymal interactions.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 108 pp. Englisch.

Seller Inventory # 9783843352178

Title
IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN ORAL CANCER
Author
Shankargouda Patil
Publisher
LAP LAMBERT Academic Publishing Sep 2010
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3843352178
ISBN 13
9783843352178
Item weight
179 grams
Dimensions
220x150x8 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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