Histopathological Classification & Grading System Of OSCC

Language: English

Published by LAP LAMBERT Academic Publishing

3330068957 / 9783330068957

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nach der Bestellung gedruckt Neuware - Printed after ordering - Histological grading has long been used to predict clinical behaviour and the prognosis of OSCCs. It was first introduced in 1920 by Broders based on the proportion of differentiated cells to undifferentiated / anaplastic cells within the entire tumour cell population and graded as highly/well, moderately, poorly differentiated and undifferentiated tumours. Bryne et al modified the Anneroth grading system, hypothesizing that the morphological features within the invasive fronts are important in prediction of a tumour's clinical behaviour and prognosis. His hypothesis was that the tumour cells at the invasive fronts of the tumour are likely to be those which metastasize, so that their features are likely to be more predictive than those in the bulk of the tumour. Based on various molecular features, later studies also highlighted that the exclusion of central and superficial parts of tumours would increase the prognostic power of any grading system as these latter areas did not represent the metastasizing phenotype. The modified malignancy grading system of Bryne et al. graded only the most anaplastic areas at the invasive fronts of the tumours.

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Bibliographic details

Title
Histopathological Classification & Grading System Of OSCC
Author
Ankur Bhargava
Publisher
LAP LAMBERT Academic Publishing
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3330068957
ISBN 13
9783330068957
Item weight
173 grams
Dimensions
220x150x7 mm

AHA-BUCH GmbH

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