HPLC-UV Method development for Fixed Dose Pharmaceutical Formulations

Language: English

Published by LAP LAMBERT Academic Publishing Mär 2026, 2026

6209779719 / 9786209779718

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This item is printed on demand - Print on Demand Titel. Neuware -Estimation of imeglimin hydrochloride in human plasma by HPLC-UV. The estimation of drugs by RP-HPLC (reverse phase chromatography) was chosen since it is advised for use with ionic and mild to non-polar compounds. Simple, specific, and superior in terms of efficiency, stability, and reproducibility is reverse phase chromatography. For the separation of imeglimin, the C18 column 250 x 4.6 mm, 5 µm particle size was chosen. In the mobile phase, various solvent solutions were tested and combined for optimum performance. Imeglimin hydrochloride (4 µg/ml) in buffer, pH 4 for Acetonitrile: Water (70:30), a concentration range (8-40 and 0.5-4 µg/ml) displaying excellent peak and a sizable resolution level. Having the mobile phase run at 1ml/min, photodiode array detectors were used to detect both analytes at 215 nm. The method was validated in different concentration ranges in human plasma. Imeglimin inter and intra-run precision was measured at less than 3.60% and had an accuracy of less than 1.869%. imeglimin in human plasma was validated by linearity, recovery matrix, and stability. The retention time of IMEG is 4.8 minutes in plasma. Suggested method denotes that it is cost-effectiveVDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 52 pp. Englisch.…

Seller Inventory # 9786209779718

Title
HPLC-UV Method development for Fixed Dose Pharmaceutical Formulations
Author
Sonia Yadav
Publisher
LAP LAMBERT Academic Publishing Mär 2026
Publication year
2026
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6209779719
ISBN 13
9786209779718
Item weight
96 grams
Dimensions
220x150x4 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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AbeBooks seller since January 23, 2017

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