The first edition to A Guide to Bone Marrow Transplantation was published 10 years ago. At that time we perceived a need for an introductory text to the area of marrow transplantation, a rapidly developing field with few general texts avail� able. Since then the situation has changed dramatically. Several introductory texts, therapeutic manuals and comprehensive volumes have been published. There is a heightened awareness of the availability, utility and potential of bone marrow transplantation, and of peripheral blood stem cell transplantation in particular. In many cases stem cell transplantation is being practiced by physi� cians as a standard therapy. For those reasons we weighed carefully the question whether the Guide was still useful or even had a place. The feedback we received from physicians in practice or in training (including both hematologists and other physicians), as well as from nurses, physician's assistants, nurse practitioners, and other personnel in� volved in one way or another in hematopoietic stem cell transplantation indicat� ed that such a text was still desirable as an introduction that focused on princi� ples rather than the latest up-to-date results.

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This book provides an introduction to marrow and peripheral blood stem cell transplantation (including cord blood transplants), emphasizing the principles of this rapidly evolving area. A brief historical perspective is given and the latest developments are discussed. Particular attention is given to the rationale and indications for transplantation, the selection of donors and source of stem cells, and the separation, expansion and manipulation of stem cells. Essential aspects of histocompatibility, preparative regimens used in stem cell transplantation, the use of hematopoietic growth factors and cytokines, the pathophysiology of the graft-versus-host reaction, and the management of complications are dealt with. This book should provide the practicing internist, pediatrician, hematologist, and oncologist as well as other physicians in training or in practice, physicians' assistants, nurses, and students with the information necessary to understand the concepts of stem cell transplantation and to include transplantation in the treatment planning soon after a diagnosis has been established. The text should also be useful to the physician who resumes the patients' care when they return from the transplant center.

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