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Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products

Terrence P. Tougas

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ISBN 10: 1461462959 / ISBN 13: 9781461462958
Published by Springer-Verlag Gmbh Mai 2013, 2013
New Condition: Neu
From Agrios-Buch (Bergisch Gladbach, Germany)

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Neuware - Aerodynamic particle size characteristics of orally inhaled products (OIPs) are critical to their performance. Testing based on cascade impaction has been the primary tool used to characterize this critical quality attribute and is a regulatory expectation for Quality Control purposes. In recent years, there have been substantial efforts directed at improving aerodynamic particle size determinations. Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products brings together for the first time a review of best practices for performing cascade impactor testing with a thorough discussion of the newly introduced concepts of abbreviated impactor measurements (AIM) and efficient data analysis (EDA). Topics covered include: Review of pharmacopeial methods (US and European) for aerodynamic particle size distributions (APSD) assessment of OIPs Physical processes that underlie aerosol formation from OIPs and the mechanisms that effect the APSD Good cascade impactor practice (GCIP) related to either full resolution or abbreviated impactor measurements. Introduction of the AIM and EDA concepts Selection of the type of testing through the development lifecycle of an OIP Theoretical basis for EDA Performance evaluation of EDA as a quality control element Case studies related to the application of EDA Experimental studies validating the AIM concept conducted by European Pharmaceutical Aerosol Group (EPAG) and the Cascade Impaction Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS). Regulatory and compendial pathways to adoption of AIM and EDA Exploration and extension of AIM as a potential approach to measures more predictive of particle deposition in the human respiratory tract. This comprehensive volume was written by a group of prominent international experts in aerosol testing led by members of the Cascade Impaction Working Group of IPAC-RS. IPAC-RS is an international association of pharmaceutical companies committed to advancing consensus-based, scientifically driven standards and regulations for orally inhaled and nasal drug products. 442 pp. Englisch. Bookseller Inventory # 9781461462958

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Bibliographic Details

Title: Good Cascade Impactor Practices, AIM and EDA...

Publisher: Springer-Verlag Gmbh Mai 2013

Publication Date: 2013

Binding: Buch

Book Condition:Neu

About this title

Synopsis:

The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic particle size distribution (APSD) measurements through the use of CI stage groupings is not the most effective decision-making tool for OIP quality control (QC) in comparison with newly introduced, mutually-independent efficient data analysis (EDA) metrics that can be derived either from full resolution or abbreviated impactor measurements (AIM).

From the Back Cover:

Aerodynamic particle size characteristics of orally inhaled products (OIPs) are critical to their performance.  Testing based on cascade impaction has been the primary tool used to characterize this critical quality attribute and is a regulatory expectation for Quality Control purposes.  In recent years, there have been substantial efforts directed at improving aerodynamic particle size determinations.

 

Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products brings together for the first time a review of best practices for performing cascade impactor testing with a thorough discussion of the recently introduced concepts of abbreviated impactor measurements (AIM) and efficient data analysis (EDA).  

 

Topics covered include:

 

·         Review of pharmacopeial methods (US and European) for assessment of aerodynamic particle size distribution (APSD) of OIPs.

·         Physical processes that underlie aerosol formation from OIPs and the mechanisms that affect the APSD.

·         Good cascade impactor practice (GCIP) related to either full resolution or abbreviated impactor measurements. 

·         Introduction of the AIM and EDA concepts.

·         Selection of the type of testing through the development lifecycle of an OIP.

·         Theoretical basis for EDA.

·         Performance evaluation of EDA as a quality control element.

·         Case studies related to the application of  EDA. 

·         Experimental studies validating the AIM concept conducted by European Pharmaceutical Aerosol Group (EPAG) and the Cascade Impaction Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS). 

·         Regulatory and compendial pathways to adoption of AIM and EDA.

·         Exploration and extension of AIM as a potential approach to measures that could be more predictive of particle deposition in the human respiratory tract. 

 

This comprehensive volume was written by a group of prominent international experts in aerosol testing led by members of the Cascade Impaction Working Group of IPAC-RS.  IPAC-RS is an international association of pharmaceutical companies committed to advancing consensus-based, scientifically driven standards and regulations for orally inhaled and nasal drug products.

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