Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Language: English

Published by Springer, Birkhäuser Okt 2018, 2018

3030008525 / 9783030008529

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This item is printed on demand - Print on Demand Titel. Neuware -This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C¿S coupling.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 192 pp. Englisch.

Seller Inventory # 9783030008529

Title
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Author
Raphael Enoque Ferraz de Paiva
Publisher
Springer, Birkhäuser Okt 2018
Publication year
2018
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3030008525
ISBN 13
9783030008529
Item weight
459 grams
Dimensions
241x160x17 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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