Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Language: English
Published by Springer International Publishing, 2019
- Softcover
- New
Condition: New
£ 79.56
Quantity: Over 20 available
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Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil Presents an innovative approach, using gold chemistry to target zinc finger proteinsExplores the use of Travelling-Wave Ion Mobility coupled with Mas.
Seller Inventory # 337743312
- Title
- Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
- Author
- Raphael Enoque Ferraz de Paiva
- Publisher
- Springer International Publishing
- Publication year
- 2019
- Condition
- New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 3030131505
- ISBN 13
- 9783030131500
- Seller catalogs
- Mathematik/Naturwissenschaften/Technik/Medizin
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
"Synopsis" may belong to another edition of this title.
From the Back Cover
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
"About the title" may belong to another edition of this title.
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