Genetic variants in estrogen signaling pathways : Significance to cardiovascular physiology and pathophysiology

Language: English

Published by VDM Verlag Dr. Müller, 2009

3639155556 / 9783639155556

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Estrogen has a number of important beneficial effectsin the cardiovascular system. We hypothesized thatgenetic variants in the estrogen receptor alpha(ERalpha) gene may cause variable sensitivity to thehormone and influence an individual s risk ofcardiovascular disease, along with otherestrogen-sensitive phenotypes. This work explores therole of ERalpha in the mediation of theatheroprotective effects of estrogen and identifiesregulatory regions in the ERalpha gene important incardiovascular tissue. It identifies novel geneticvariants in these regions and examines their effecton expression of the receptor in vitro, and theirassociation with estrogen sensitive phenotypes indifferent study populations. The identification ofgenetic variations associated with altered estrogenresponse is of potential public health importance. Insights may be gained into the pathogenesis ofcardiovascular as well as other estrogen sensitivediseases contributing to the development andapplication of newer therapies for these disorders.

Seller Inventory # 9783639155556

Title
Genetic variants in estrogen signaling pathways : Significance to cardiovascular physiology and pathophysiology
Author
Gemma Figtree
Publisher
VDM Verlag Dr. Müller
Publication year
2009
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3639155556
ISBN 13
9783639155556
Item weight
362 grams
Dimensions
22.00x15.00x1.30 cm

AHA-BUCH GmbH

Einbeck, Germany

5-star seller

AbeBooks seller since August 14, 2006

Shipping rates from Germany to U.S.A.

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