Gastrointestinal Inflammations and Gut Microbiota: Pathophysiology, Management, and Emerging Therapies

This book offers a comprehensive and multi-faceted examination of gastrointestinal inflammations, discussing factors that impact gut health. The initial chapters establish a foundational understanding of gastrointestinal inflammations and the critical role of the gut microbiota. The book then delves into the complex pathophysiology and various risk factors associated with these conditions, offering insights into the latest diagnostic, screening, and prevention techniques. It explores the dynamic interactions between the gut and the brain as well as the biochemical interplays involving short-chain fatty acids, reactive oxygen species, and superoxide dismutases. Additionally, the book thoroughly discusses the impact of genetics on gastrointestinal health, the interactions between antibiotics and gut microbiota, and the pivotal role of the immune system in inflammation. It highlights advancements in diagnostic technologies and gut microbiota-based strategies, along with the use of nanoparticles in treatment. The book also examines the psychological aspects associated with gastrointestinal inflammations, emphasizing the importance of mental health for physical well-being. It assesses the potential of functional foods, various types of nanocarriers, and plant-based bioactives in managing gastrointestinal inflammations. As such, this book is primarily intended for researchers and students in the fields of gastroenterology and microbiology.

Key Features:

• Provides an extensive overview of gastrointestinal inflammations, starting from the basic concepts of the gut microbiota to complex pathophysiological aspects
• Delves into the latest advancements in diagnostic, screening, and prevention techniques, highlighting cutting-edge technologies and approaches in gastroenterology
• Explores the role of the immune system and the impact of genetics and diet on gastrointestinal health
• Examines use of probiotics, prebiotics, postbiotics, and various nanotechnology-based approaches for gastrointestinal inflammation management
• Emphasis on the psychological factors associated with gastrointestinal inflammations

Dr. Neeraj Mishra has been serving as a Professor at the Amity Institute of Pharmacy, Gwalior, since July 2019. He brings approximately 20 years of experience in teaching and research. Dr. Mishra has published over 100 papers of international and national significance, focusing on novel drug delivery systems, oral delivery of synbiotics, localized drug delivery, and targeted and controlled drug delivery using nanocarriers and microparticles for treating breast and colon cancer, as well as neurodegenerative disorders. He has also edited more than 15 books and authored 25 book chapters. He is the recipient of the “Distinguished Professor Award” (2019) from DST-NSTMIS, SPAICS, Indore, Madhya Pradesh, and the “Outstanding Scientist Award” (2020) from the 6th International Scientist Awards on Engineering, Science, and Medicine, held in Chennai, India. Further, Dr. Mishra received the “Distinguished Professor Award” in 2021 from the Indian Pharmaceutical Association, MP State Branch, Indore, and the “Best Academician Award” at the Indian Pharmacy Graduate Association’s M.P. State International Conference, held on May 6, 2023, at the DAVV Auditorium, Indore, India.

Dr. Sumel Ashique has been working as an Assistant Professor at Bengal College of Pharmaceutical Sciences & Research, Durgapur 713212, West Bengal, India. He has 4 years of teaching experience. He has achieved 80 publications in International and national accredited reputed journals. He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. He is working as potential reviewer for many well-known publishers (Elsevier, Springer, Dove Press, and Bentham Sc.). He has also five granted patents from IP and Australia, 20 published book chapters in Bentham, Springer, Elsevier, Bentham and Taylor & Francis. Currently is editing 14 books under CRC Press, Elsevier, Taylor and Francis, Wiley, Nova Science and Springer. He has published 80+ papers including research, reviews, column articles, editorials in Scopus, and WOS indexed. He is serving as guest editor in JoVE journal (IF 1.2, Scopus & WOS indexed), Current Probiotics (Bentham Science) & Current Indian Science Journal. He is a potential reviewer for Elsevier, Springer, Taylor & Francis and Wiley journals for expertise in the field of targeted drug delivery, nanotechnology, gut-microbiome and postbiotics. Current he is pursuing his PhD degree from Lovely Professional University, Punjab, India (NAAC A++) in the Pharmaceutical Science department.

Dr. Anoop Kumar is currently serving as an Assistant Professor in the Department of Pharmacology and Clinical Research at Delhi Pharmaceutical Sciences & Research University (DPSRU), New Delhi, India. Previously, he held the position of Assistant Professor in the Department of Pharmacology and Toxicology at the National Institute of Pharmaceutical Education and Research (NIPER), Raebareli. He has also served as an Associate Professor and Officiating Head in the Department of Pharmacology at ISF College of Pharmacy, Moga, Punjab. Additionally, Dr. Kumar has worked as a research scientist in the Medical Affairs and Clinical Research Department at Sun Pharmaceutical Limited, Gurugram, and at the Translational Health Science and Technology Institute (THSTI), Faridabad, India. Dr. Kumar has authored over 80 research and review articles and 15 book chapters in internationally renowned journals. He is also the author of three books. He has received research grants from the Indian government. His research interests include drug repurposing using computational, in vitro, and in vivo techniques, meta-analysis, signal analysis in pharmacovigilance, and pharmacoeconomic studies.