Gadd45 Stress Sensor Genes

Liebermann, Dan A. (EDT); Hoffman, Barbara (EDT)

ISBN 10: 1493953907 / ISBN 13: 9781493953905

Published by Springer, 2016

Seller Inventory # 27232034-n

Synopsis:

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.

About the Author: Associate Professor, Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center at Dallas

Bibliographic Details

Title: Gadd45 Stress Sensor Genes
Publisher: Springer
Publication Date: 2016
Binding: Soft cover
Condition: New