Functional Selectivity of G Protein-Coupled Receptor Ligands. New Opportunities for Drug Discovery
Language: English
Published by Humana Press, New York, 2009
Series: Book 5 of 29 - The Receptors
- Hardcover
- Used
Seller: Research Ink, Takoma Park, MD, U.S.A.Research Ink
AbeBooks seller since August 1, 2000
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- Title
- Functional Selectivity of G Protein-Coupled Receptor Ligands. New Opportunities for Drug Discovery
- Author
- Neve, Kim A., Ed.
- Publisher
- Humana Press, New York
- Publication year
- 2009
- Condition
- Very Good
- Book Type
- book
- Binding
- Hardback
- Language
- English
- ISBN 10
- 1603273344
- ISBN 13
- 9781603273343
- Series
- Book 5 of 29: The Receptors
- Seller catalogs
- Physiology
Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.
"Synopsis" may belong to another edition of this title.
From the Back Cover
Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.
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Research Ink
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