Functional Properties of Vascular Mesenchymal Stem Cells (Paperback)

Language: English

Published by Our Knowledge Publishing, 2026

6630310829 / 9786630310825

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Paperback. Diabetes mellitus (DM) is associated with the development of macroangiopathy and accelerated atherosclerosis, major causes of morbidity and mortality. This study evaluated the biological properties of arterial and venous vascular mesenchymal stem cells (vMSCs) in rats with streptozotocin-induced DM. After eight weeks, the diabetic animals exhibited hyperglycemia, weight loss, and increased collagen deposition in the aorta, indicating macroangiopathy. Although the number of vMSCs, their proliferation, and the expression of cellular markers remained unchanged, arterial vMSCs exhibited a significant reduction in osteogenic, adipogenic, and endothelial differentiation capacity. Insulin treatment prevented both the metabolic changes and the functional impairment of these cells. The results demonstrate that chronic DM selectively affects the differentiation potential of arterial vMSCs, suggesting that these changes may contribute to the pathogenesis of diabetic macroangiopathy and represent a potential target for future therapeutic strategies. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

Seller Inventory # 9786630310825

Title
Functional Properties of Vascular Mesenchymal Stem Cells (Paperback)
Author
Diogenes Rodrigo Maronezzi de Paula
Publisher
Our Knowledge Publishing
Publication year
2026
Condition
new
Binding
Paperback
Language
English
ISBN 10
6630310829
ISBN 13
9786630310825

Grand Eagle Retail

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