Fragment-Based Drug Discovery : Lessons and Outlook
Language: English
Published by Wiley-VCH, 2016
- Hardcover
- Used
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- Title
- Fragment-Based Drug Discovery : Lessons and Outlook
- Author
- Erlanson, Daniel A. (EDT); Jahnke, Wolfgang; Kubinyi, Hugo; Folkers, Gerd
- Publisher
- Wiley-VCH
- Publication year
- 2016
- Condition
- As New
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 352733775X
- ISBN 13
- 9783527337750
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.
The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.
"Synopsis" may belong to another edition of this title.
About the Author
Wolfgang Jahnke is a Director and Leading Scientist at the Novartis Institutes for Biomedical Research in Basel, Switzerland. His major interests are Structural Biophysics and Fragment-based Drug Discovery. He has received several honors, among them the Industrial Investigator Award from the Swiss Chemical Society, and several Novartis-internal Awards. Dr. Jahnke received his PhD from the TU Munchen, working with Horst Kessler on the development and application of novel NMR methods. Prior to joining Novartis, he worked with Peter Wright at the Scripps Research Institute in La Jolla.
"About the title" may belong to another edition of this title.
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