Formulation and optimization of floating matrix tablets of salbutamol

Language: English

Published by LAP LAMBERT Academic Publishing Jan 2019, 2019

6134997846 / 9786134997843

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This item is printed on demand - Print on Demand Titel. Neuware -Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its dosing frequency. Accordingly, floating tablets were prepared by wet granulation technique and drug release analysis was performed by HPLC. The effects of polymer level, polymer type (XG or HPMC), polymer ratio (XG/HPMC; 1:1, 1:3, 3:1) and NaHCO3 level on floating lag time, floating duration, cumulative release within 1 hr, and release rate were investigated. From preliminary studies, the polymer with 1:3 (XG:HPMC) ratio and NaHCO3 were selected as significant factors and cumulative release at 1 hr and release rate were chosen as significant responses, respectively. Hence, the effect of these factors was further studied and optimized by central composite design. The most desirable representative optimal point was obtained at 24.79% of XG/HPMC and 5% of NaHCO3 having a release rate of 28.4.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 52 pp. Englisch.…

Seller Inventory # 9786134997843

Title
Formulation and optimization of floating matrix tablets of salbutamol
Author
Zewdu Yilma Dlie
Publisher
LAP LAMBERT Academic Publishing Jan 2019
Publication year
2019
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6134997846
ISBN 13
9786134997843
Item weight
96 grams
Dimensions
220x150x4 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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