Formulation and evaluation of fast dissolving films of linagliptin

Language: English

Published by LAP LAMBERT Academic Publishing Feb 2020, 2020

6200567506 / 9786200567505

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Softcover

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This item is printed on demand - Print on Demand Titel. Neuware -Linagliptin is novel anti-diabetic drug used for the treatment of type 2 diabetes It is belongs to the class of dpp-4 inhibitor. Linagliptin undergoes first pass metabolism so its bioavailability is low (30 %). Fast dissolving films of Linagliptin prepared by using natural polymers like Pullulan, pectin, gelatin and sodium alginate, using plastsizer PEG 400 ,citric acid and aspartame as sweetener. Based on trial batches pullulan was select for further screening using Factorial design. Pullulan and PEG 400 selected as independent variables. Prepared films was analyzed for various parametrs like weight variation, thickness, folding endurance, drug content, tensile strength, % elongation, disintegration time and % Drug release. From all the formulations, formulation F3 which contains Pullulan film forming polymer was optimized because it gives maximum drug release in 8 min which was maximum drug release in less time in all formulations. Also F3 have disintegration time 21 sec and have good mechanical properties. Pullulan found significant factor for folding endurance, disintegration time and drug release.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch.…

Seller Inventory # 9786200567505

Title
Formulation and evaluation of fast dissolving films of linagliptin
Author
Mrugesh Pandit
Publisher
LAP LAMBERT Academic Publishing Feb 2020
Publication year
2020
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6200567506
ISBN 13
9786200567505
Item weight
161 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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Impressum Thorsten Retsch Buchversand Mimpf2000 Oberölschnitz 16 95517 Emtmannsberg Deutschland Telefon: 09209-2023188 Email: mimpf2000@online.de USt-ID-Nr.: DE 235096871 Wir führen gebrauchte Bücher aus allen Sparten der Literatur

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