Formulation Of Phenytoin Complexes For Dissolution Enhancement

Language: English

Published by LAP LAMBERT Academic Publishing Mai 2014, 2014

3659537055 / 9783659537059

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This item is printed on demand - Print on Demand Titel. Neuware -Phenytoin Inclusion complex prepared by microwave method was used for preparation of FDT by different superdisintegrants by direct compression method. From that the cross-povidone (5%) containing inclusion complex was maximum DT, Wetting time and In-vitro drug release. The FDT containing 1:2 ratio complexes and 5% crospovidone give minimum DT and Wetting time. Then 32 full factorial designs were applied and the tablets were synthesized using different proportions of inclusion complex and crospovidone (%) by direct compression technique. The optimum ratio was 1:2 and 5% which produced highest DT (10.01 sec), Wetting time (9.45 sec.) and cumulative percent drug release (99.51% at 40 min). The solubility and dissolution pattern of Phenytoin were found to be carrier ratio dependent. From evaluation parameters and formulation characterization, it can be concluded that solubility of drug was improved by MW method compared to SE method and pure drug. The tablet contain optimum ratio of inclusion complex and optimum concentration of superdisintegrants give maximum drug release in minimum time period.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 152 pp. Englisch.…

Seller Inventory # 9783659537059

Title
Formulation Of Phenytoin Complexes For Dissolution Enhancement
Author
Patel Maulika
Publisher
LAP LAMBERT Academic Publishing Mai 2014
Publication year
2014
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659537055
ISBN 13
9783659537059
Item weight
244 grams
Dimensions
220x150x10 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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