Formulation and Evaluation of Sublingual Tablet of Rabeprazole Sodium

Language: English

Published by LAP LAMBERT Academic Publishing Mai 2014, 2014

3659540188 / 9783659540189

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This item is printed on demand - Print on Demand Titel. Neuware -The present work introduces a new tablet system for sublingual administration in which the tablet is based on interactive mixtures of components, consisting of carrier particles partially covered by fine dry particles of the drug, in this case Rabeprazole sodium. In the interests of increasing retention of the drug at the site of absorption in the oral cavity, a bioadhesive component was also added to the carrier particles. With this approach, it is possible to obtain rapid dissolution in combination with bioadhesive retention of the drug in the oral cavity. Rabeprazole sodium is an anti ulcer drug having oral bioavailability 52% due to hepatic first pass metabolism. This work aims to avoid degradation of drug in acidic environment of stomach. In this study, Rabeprazole sodium sublingual tablets were prepared by direct compression method using different bioadhesive polymers such as HPMC K4M and chitosan and sodium starch glycolate as a superdisintegrant. The effect of different concentration of polymers and superdisintegrating agents was measured by applying Box-Behnken design.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 136 pp. Englisch.…

Seller Inventory # 9783659540189

Title
Formulation and Evaluation of Sublingual Tablet of Rabeprazole Sodium
Author
Ankita Thacker
Publisher
LAP LAMBERT Academic Publishing Mai 2014
Publication year
2014
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659540188
ISBN 13
9783659540189
Item weight
221 grams
Dimensions
220x150x9 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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