Formulation and Evaluation of Propranolol Hydrochloride Floating Beads

Language: English

Published by LAP LAMBERT Academic Publishing Jun 2023, 2023

6206181588 / 9786206181583

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This item is printed on demand - Print on Demand Titel. Neuware -The objective of the present study was to develop floating alginate beads of Propranolol hydrochloride for oral use with a point of view to treat hypertension. Propranolol is retained in the stomach for a prolonged period of time. The drug is stable and easily absorbable in an acidic medium. Its elimination half-life is about 3-6 hrs and its bioavailability is up to 25 %. Among the various approaches to achieve gastric retention time, the gastric floating drug delivery system is one approach selected to prolong the floating behavior of the alginate beads. For this purpose sodium alginate was used as a matrix bead forming agent, mineral oil as buoyancy imparting agent, and hydrophilic swellable polymers like HPMC K100, Eudragit S-100, Agar, Starch, and SSG were used as key ingredients to achieve the objective.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 52 pp. Englisch.

Title
Formulation and Evaluation of Propranolol Hydrochloride Floating Beads
Author
Chandra Sekhara Rao Gonugunta
Publisher
LAP LAMBERT Academic Publishing Jun 2023
Publication year
2023
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6206181588
ISBN 13
9786206181583
Item weight
96 grams
Dimensions
220x150x4 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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