Formulation Of Drug Delivery Systems Based On Gel-forming Polymers

Language: English

Published by LAP LAMBERT Academic Publishing Okt 2014, 2014

3659629782 / 9783659629785

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This item is printed on demand - Print on Demand Titel. Neuware -Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of tetracycline HCl (Tc HCl) films based on gel forming polymers as drug release regulators for local treatment of periodontal pockets. Different film formulations were simply prepared by 'solvent casting technique'. Films were suitable for intra-pocket application, they were hard enough to be easily inserted into the periodontal pocket. Immediately after application, they hydrate by the action of gingival crevicular fluid forming a bioadhesive gel which allow the formulation to get access to the entire pocket. Films exhibited a sustained release pattern. The stability study for the selected formula (Tc HCl/Na CMC) indicated that the five months storage period did not significantly influence the drug release behavior or its antibacterial activity. Clinical evaluation indicated that the film was well tolerated, no signs of irritation or prolonged foreign body sensation were reported by the test subjects and significant reduction in the pocket depth was observed.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 112 pp. Englisch.

Seller Inventory # 9783659629785

Title
Formulation Of Drug Delivery Systems Based On Gel-forming Polymers
Author
Abeer Kassem
Publisher
LAP LAMBERT Academic Publishing Okt 2014
Publication year
2014
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659629782
ISBN 13
9783659629785
Item weight
185 grams
Dimensions
220x150x8 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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