Formulation Development & Characterization of Matrix Tablet for CTDD

Language: English

Published by Scholars' Press Sep 2021, 2021

6138960289 / 9786138960287

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Softcover

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This item is printed on demand - Print on Demand Titel. Neuware -The present investigation involves formulation development and characterization pg matrix tablet for colon targeted delivery with a view to extended the drug release in colonic segment. The extended release matrix tablet were formulated by using the combination of release retardant polymer. The polymer used were hydroxypropylmethylcellulose, eudragit L-30.D55. tablet were prepared by wet granulation technique using water. The granules were subjected to pre-compression evaluation such as bulk density, tap density, compressibility index, hausners ratio, particle size distribution and loss on drying. It was concluded that granules exhibited good compressibility and flow property. Prepared tablet were also evaluated for post-compression parameter like hardness, thickness, in-vitro dissolution, stability studies. Amongs the eight formulations F8 showed good results In-vitro dissolution studies were carried out for 12 hrs using 0.1 N HCl for 2 hrs and pH 7.2 for remaining 10 hrs. In-vitro dissolution studies showed that the formulation F8 releases 91.9 % of drug. Stability studies were carried out for formulayion F8 at 25¿C/60% RH and 40¿C/75% RH for 30 days.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 100 pp. Englisch.…

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Bibliographic details

Title
Formulation Development & Characterization of Matrix Tablet for CTDD
Author
Vikas Ahirrao
Publisher
Scholars' Press Sep 2021
Publication year
2021
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6138960289
ISBN 13
9786138960287
Item weight
167 grams
Dimensions
220x150x6 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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