Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications

Five-membered bioactive heterocycles offer an in-depth exploration of the synthesis, properties, and wide-ranging medical applications of these molecular structures. From serving as the structural core of numerous pharmaceutical agents to directly engaging with biological targets, these molecules play a pivotal role in drug discovery and development. With applications spanning from antimicrobial and anticancer agents to treatments for neurological disorders, these compounds are integral to the design of targeted therapies. Their versatility and bioactivity make them valuable models for drug discovery, offering novel approaches to addressing a wide range of medical challenges. As research advances, the continued exploration of five-membered N- and O-heterocycles may help with the development of innovative treatments and the improvement of healthcare outcomes. Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications examines the synthetic methodologies employed in the construction of five-membered heterocycles, providing insights into the strategies and techniques utilized to access these diverse compounds. It delves into their synthetic pathways, including both traditional and modern synthetic approaches, along with the key factors influencing regio- and stereo-selectivity. This book covers topics such as bioactivity, chemistry, and pharmacology, this book is an excellent resource for chemists, pharmaceutical researchers and professionals, biochemists, molecular biologists, graduate and postgraduate students, academicians, healthcare professionals, and more.

Shrikaant Kulkarni , Ph.D., is currently working as a Research Professor at Sanjivani University, Kopargaon, India and as an Adjunct Professor, at the Faculty of Business, Victorian Institute of Technology, Melbourne, Australia, and Adjunct Professor at Chitkara University, Punjab, India. Dr. Kulkarni has been a senior academician and researcher for 42 years. He has delivered invited lectures and conducted sessions at national and international conferences and faculty development programs. He has guided many major and minor projects in areas like engineering chemistry, green chemistry, nanotechnology, analytical chemistry, catalysis, chemical engineering materials, industrial organization, and management, Advanced AI, and Educational Technology. He has published over 100+ research papers in national and international journals and conferences of repute. He has edited 36 books including four books in Advanced AI, and authored 100+ book chapters in books published by CRC, Springer Nature, Apple Academic Press, Elsevier, Wiley, and IET. He authored four textbooks in engineering chemistry too. Dr Kulkarni possesses MSc, MPhil, and PhD degrees in Chemistry and Master’s degrees in Economics, Business Management, and Political Science.Two of his Patents have been published and two more are applied for grant. He was invited by UNESCO for an invited talk on “ Green Chemistry Education for Sustainable Development “ at the International Conference on Green Chemistry, Bangkok, and was well received by international Jury members and dignitaries from across the world. E-mail: shrikaant.kulkarni@vit.edu.au Mob: +91-9970663353

Dr. Hemantkumar Akolkar , Ph.D., Working as Assistant Professor, Department of Chemistry, Rayat Shikshan Sanstha’s Abasaheb Marathe Arts and New Commerce, Science College, Rajapur, Dist- Ratnagiri, Maharashtra, India Dr. Hemantkumar N. Akolkar is an academician and researcher for last 14 years at both undergraduate and postgraduate level. He has taught subjects like Heterocyclic Chemistry, Green Chemistry, Organic Spectroscopy, Organic Stereochemistry, Chemistry of Natural Products during his career. He possesses Masters in Organic chemistry and Ph.D. in Chemistry from Savitribai Phule Pune University, Pune. He has 60+ research papers in national and international journals and conferences of repute, 6 patents, 3 books and 9 book chapters. His areas of interest are Heterocyclic Chemistry, Synthetic Organic Chemistry and Green Chemistry. He is reviewer of several journals in Chemistry of international repute.

Bapurao B. Shingate , working as an Associate Professor in Organic Chemistry at Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada Univeresity, Aurangabad, Maharashtra, India Dr. Shingate has more than fifteen years of teaching and twenty-one years of research experience. He is teaching various topic to the postgraduate students like Organic reaction mechanism, Synthetic organic chemistry, Reagents in organic synthesis, Organometallic compounds, Protective groups, Retrosynthetic analysis, Classics in total synthesis, Multistep organic transformations, Asymmetric synthesis. Dr. Shingate is working on various areas of synthetic organic and medicinal chemistry and published more than 130 research papers in quality journals with good impact factors. He has published a review article in the prestigious journal Chemical Reviews (Impact factor 72.087). On his credit two Indian patents also. His total citations are 3849, h-index 35 and i-10 index is 96. He has immensely contributed in the field of design and synthesis of bioactive compounds and drug analogs, development of new synthetic methodologies, and total synthesis of natural and unnatural products. His cumulative impact factors are 506. Dr. Bapurao's contribution to teaching and research already been recognized in the university circle and national level. He has received several awards like GTEA-Best Chemistry Professor of the Year (2020), Bentham Ambassador (2018--23), ISCB-Best Teacher Award (2018), Dr. BAMU-Research Professor Award (2017), Dr. BAMU-Ideal Teacher Award (2014) and Dr. BAMU-Shikshak Pratibha Puraskar. Dr. Shingate has guided 07 Ph.D and more than 200 for M. Sc Dissertation. Dr. Shingate has delivered 175+ invited talks and BOS member in chemistry for several institutions. Dr. Shingate is editorial board member for several journals and reviewer for 60+ journals.

Vijay M Khedkar working as Associate Professor in the Department of Pharmacy at Vishwakarma University, Pune, Maharashtra, India A highly optimistic and proactive computational medicinal chemist with Ph.D. degree in Pharmaceutical Chemistry (Computational Medicinal Chemistry) and Post-doctoral research experience. Successful track record of executing lead identification and optimization projects by applying molecular modeling techniques.