Fas Ligand reverse signaling: an immunmodulatory setscrew
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Jun 2015, 2015
- Softcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 60.83
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -Binding of Fas Ligand (FasL) to the Fas receptor triggers apoptosis of the receptor-bearing cell, which plays a pivotal role for homeostasis of the immune system and during acute immune responses. Similar to other TNF family members, the intracellular FasL domain is able to transmit signals into the FasL-bearing cell ('reverse signaling'). Recently, we have described a Notch-like proteolytic processing of FasL by the proteases ADAM10 and SPPL2a, which leads to the release of the intracellular domain (FICD) into the cytoplasm. Following the cleavage event, FICD translocates to the nucleus and influences gene transcription. To study the physiological importance of FasL reverse signaling in vivo on the level of the endogenous proteins, we have established a knockout/knockin mouse model in which wildtype FasL was replaced with a deletion mutant lacking the intracellular portion (FasL Intra). Our ex vivo and in vivo findings demonstrate that FasL reverse signaling is a negative modulator of certain immune responses. It is tempting to speculate that FasL reverse signaling might be a fine-tuning mechanism to prevent autoimmune diseases. 144 pp. Englisch.…
Seller Inventory # 9783838124872
- Title
- Fas Ligand reverse signaling: an immunmodulatory setscrew
- Author
- Katharina Lückerath
- Publisher
- Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Jun 2015
- Publication year
- 2015
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3838124871
- ISBN 13
- 9783838124872
- Item weight
- 233 grams
- Dimensions
- 220x150x10 mm
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About the Author
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BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
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BuchWeltWeit Ludwig Meier e.K.
Germany
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