THE FUNCTION OF MRN COMPLEX DURING WRN FACILITATED ATM ACTIVATION

Language: English

Published by LAP LAMBERT Academic Publishing Mär 2010, 2010

3838353617 / 9783838353616

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This item is printed on demand - Print on Demand Titel. Neuware -WRN (Werner) protein is a member of the RecQ family showing helicase and exonuclease activity. WRN protein may lose function upon mutation and causes Werner syndrome (WS) which is a cancer-prone and premature aging disease. ATM (Ataxia-Telangiectasia mutated) protein initiates a signaling pathway in response to DNA double strand breaks (DSBs). Genomic disorder ataxia-telangiectasia (A-T) is associated with defective ATM. WRN protein is involved in ATM pathway activation when cells are exposed to DSBs associated with replication fork collapse. Because the Mre11-Rad50-Nbs1 (MRN) complex, a sensor of DSBs, is known to interact with WRN and ATM, we investigated whether the MRN complex mediates the WRN-dependent ATM pathway activation. In this study, we employed short-hairpin RNA to generate WRN- and Nbs1-deficient U-2 OS (osteosarcoma) cells. Cells were treated with clastogens which induce collapsed replication forks, thus provided proof for whether WRN facilitates ATM activation via MRN complex. This study serves as a basis for future investigation on the correlation between ATM, MRN complex and WRN, which will help understand the mechanism of aging and cancer.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 76 pp. Englisch.…

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Title
THE FUNCTION OF MRN COMPLEX DURING WRN FACILITATED ATM ACTIVATION
Author
Junhao Ma
Publisher
LAP LAMBERT Academic Publishing Mär 2010
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3838353617
ISBN 13
9783838353616
Item weight
131 grams
Dimensions
220x150x5 mm

buchversandmimpf2000

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