Evolving Methods for Macromolecular Crystallography

Language: English

Published by Springer-Verlag New York Inc., US, 2007

1402063148 / 9781402063145

Series: Book 184 of 241 - NATO Science Series II: Mathematics, Physics and Chemistry

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This volume comprises papers presented at the 2005 edition of the "Crystallography of Molecular Biology" courses that have been held since 1976 at the Ettore Majorana Centre for Scientific Culture in Erice, Italy. This series of courses is renowned for bringing leaders in the field of macromo- cular crystallography together with highly motivated students, in a beautiful and intimate location that encourages people to interact. The warm and informal atmosphere at these Erice conferences, especially these on cryst- lography, has helped to foster long-term scientific interactions and new int- national friendships that have often lasted for the lifetime of the scientists. The course was financed by NATO as an Advanced Study Institute and by the European Commission as a EuroSummerSchool. The papers span the breadth of material presented in the course, which emphasized the practical aspects of modern macromolecular crystallography and its applications. One must start with crystals: Bergfors showed how to improve initial crystals through seeding, while Byrne discussed the difficult problem of crystallizing membrane proteins. The collection of optimal diffraction data requires both careful preparation of cryo-cooled crystals (Garman) and proper processing of the diffraction images (Leslie). To obtain images of electron density, one needs estimates of the phases of the diffracted spots. Sheldrick presented the background to the sing- wavelength anomalous diffraction (SAD) method, which has been gaining popularity, and McCoy discussed the basis of modern maximum likelihood methods for treating information in experimental phasing.

Seller Inventory # LU-9781402063145

Title
Evolving Methods for Macromolecular Crystallography
Author
Randy J. Read
Publisher
Springer-Verlag New York Inc., US
Publication year
2007
Condition
New
Binding
Hardback
Language
English
ISBN 10
1402063148
ISBN 13
9781402063145
Edition
2007 ed.
Series
Book 184 of 241: NATO Science Series II: Mathematics, Physics and Chemistry

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