Enhancement of complexation of drug: binary and ternary mixtures

Language: English

Published by LAP LAMBERT Academic Publishing Apr 2012, 2012

384849390X / 9783848493906

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This item is printed on demand - Print on Demand Titel. Neuware -The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HPß-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HPß-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HPß-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HPß-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 120 pp. Englisch.…

Seller Inventory # 9783848493906

Title
Enhancement of complexation of drug: binary and ternary mixtures
Author
Lokesh Kumar Bhati
Publisher
LAP LAMBERT Academic Publishing Apr 2012
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
384849390X
ISBN 13
9783848493906
Item weight
197 grams
Dimensions
220x150x8 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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