Endotoxins: Structure, Function and Recognition

Peter J. Quinn

ISBN 10: 9048190770 / ISBN 13: 9789048190775

Published by Springer Netherlands, Springer Netherlands, 2010

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria.Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death.This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases.The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

Seller Inventory # 9789048190775

Bibliographic Details

• Title: Endotoxins: Structure, Function and Recognition
• Publisher: Springer Netherlands, Springer Netherlands
• Publication Date: 2010
• Language: English
• ISBN 10: 9048190770
• ISBN 13: 9789048190775
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 32D millimeters 241 millimeters width by 160 millimeters height by 32 millimeters depth
• Weight: 896 grams

About this title

Synopsis

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.