Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity (Current Topics in Microbiology and Immunology, 410)
Language: English
Published by Springer, 2017
Series: Book 266 of 322 - Current Topics in Microbiology and Immunology
- Hardcover
- New
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- Title
- Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity (Current Topics in Microbiology and Immunology, 410)
- Publisher
- Springer
- Publication year
- 2017
- Condition
- New
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 3319689282
- ISBN 13
- 9783319689289
- Series
- Book 266 of 322: Current Topics in Microbiology and Immunology
This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.
Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
"Synopsis" may belong to another edition of this title.
About the Author
Akihiko Yoshimura, PhD
Department of Microbiology and Immunology,
Keio University School of Medicine
35 Shinanomachi, Shinjyuku-ku, Tokyo
160-8582, Japan
Phone: +81-3-5363-3483
FAX: +81-3-5360-1508
yoshimura@a6.keio.jp
"About the title" may belong to another edition of this title.
Ria Christie Collections
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