ESTIMATION OF PERINDOPRIL ARGININE, INDAPAMIDE AND AMLODIPINE BY HPLC

Language: English

Published by Scholars' Press, 2022

6138968573 / 9786138968573

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nach der Bestellung gedruckt Neuware - Printed after ordering - A simple, accurate, and precise stability-indicating reverse phase high pressure liquid chromatographic method was developed and validated for the estimation of Perindopril arginine, Indapamide, and Amlodipine in the bulk and pharmaceutical dosage form. Chromatographic separation was carried out on ZORBAX RX C8 (250 mm × 4.6 mm, 5 µm) as a stationary phase with a mobile phase of gradient system of Phosphate Buffer with pH 2 containing Decane Sulphonate as ion-pairing agent (A) and Acetonitrile (B) at detection wavelength215 nm with flow rate 1.0 mL/min at column temperature 40 ºC. The tR of Perindopril, Indapamide, and Amlodipine was 31.39 ± 0.21 min, 25.73 ± 0.41min, and 36.95 ± 0.47 min, respectively. The method was linear over the concentration ranges 50-150 µg/ mL for Perindopril, 12.5-37.5 µg/ mL for Indapamide and 50-150 µg/ mL for Amlodipine. The LOD was 0.99 µg/ mL for Perindopril,0.87 µg/ mL for Indapamide and 3.99 µg/ mL for Amlodipine. The LOQ was3.02 µg/ mL for Perindopril, 2.6 µg/ mL for Indapamide and 12.08 µg/ mL for Amlodipine.…

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Title
ESTIMATION OF PERINDOPRIL ARGININE, INDAPAMIDE AND AMLODIPINE BY HPLC
Author
Jayant Dave
Publisher
Scholars' Press
Publication year
2022
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6138968573
ISBN 13
9786138968573
Item weight
96 grams
Dimensions
220x150x4 mm

AHA-BUCH GmbH

Einbeck, Germany

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