EBNA1 and Epstein-Barr Virus Associated Tumours

Lori Frappier

ISBN 10: 146146885X / ISBN 13: 9781461468851

Published by Springer New York, Springer US Apr 2013, 2013

About this Item

Neuware -This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers. EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. Thisbook offersa currentsynopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 52 pp. Englisch.

Seller Inventory # 9781461468851

Bibliographic Details

• Title: EBNA1 and Epstein-Barr Virus Associated Tumours
• Publisher: Springer New York, Springer US Apr 2013
• Publication Date: 2013
• Language: English
• ISBN 10: 146146885X
• ISBN 13: 9781461468851
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 4D millimeters 235 millimeters width by 155 millimeters height by 4 millimeters depth
• Weight: 96 grams

About this title

Synopsis

This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers.   EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This book offers a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas.

About the Author

Lori Dawn Frappier, Ph.D., is a Professor in the Department of Molecular Genetics at the University of Toronto and a Canada Research Chair in Molecular Virology. She specializes in researching mechanisms by which viruses persist and induce cancer in human cells. According to Scopus, Dr. Frappier has an H-index of 25; she has published over 80 papers and has been cited over 2700 times. Please see attached short CV for additional details.