Diuretics

Language: English

Published by Springer, Springer Spektrum Dez 2011, 2011

3642795676 / 9783642795671

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This item is printed on demand - Print on Demand Titel. Neuware -The first edition of this handbook appeared exactly twenty-five years ago. Due to enormous changes in the area of diuretics, the second edition has had to be completely revised. Substantial progress has been made in the functional anatomy of the kidney and in the concepts of how substances and ions are specifically transported across the various nephron segments. No one could have foreseen twenty-five years ago that the late 1980s and the early 1990s have provided us with methodologies to study transport events not only at the single cell level, but even at the level of the single transporter molecule. Many of the transporters for ions and organic substances have been cloned meanwhile by the new methods of molecular biology, and their function can be described more precisely by new transport studies such as the patch-clamp technique. These new insights have also led to a new understanding of how the currently used diuretics act. Just a few months ago, the Na+Cl- co-transporter, which is the target of thiazides, the Na+2CI-K+ co-transporter, which is the target of furosemide, and the amiloride sensitive Na+ channel were cloned. Hence, the targets of diuretics have now been identified at the molecular level. In addition, during the past twenty-five years extensive studies have been performed on the pharmacokinetics of diuretics. We have learned how changes in liver metabolism and altered renal excretion influence the pharmacology of this class of compounds.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 544 pp. Englisch.…

Seller Inventory # 9783642795671

Title
Diuretics
Author
Rainer F. Greger
Publisher
Springer, Springer Spektrum Dez 2011
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3642795676
ISBN 13
9783642795671
Item weight
814 grams
Dimensions
235x155x30 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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