Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement Of A Poorly Soluble Model Drugs Using Different Formulation Approaches For Immediate Release
Srivastava, Vikas Kumar; Mishra, Garima; Srivastava, Vikas Kumar; Mishra, Garima
ISBN 10: 3659453358 ISBN 13: 9783659453359
Published by Lap Lambert Academic Publishing, 2013
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Revaluation Books, Exeter, United Kingdom
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144 pages. 8.66x5.91x0.33 inches. In Stock. Seller Inventory # 3659453358
Synopsis:
The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.
About the Author: The author is Vikas Kumar Srivastava S/o late Om Prakash Srivastava, have completed his B.Pharm (2006-2010) from LIMT, Gr. Noida with 81%. He had completed M.Pharma (Pharmaceutics) from I.T.S Paramedical (Pharmacy) college, Ghaziabad, affiliated to Maha Maya Technical University, Noida. He had published many review and research articles.
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Bibliographic Details
Title: Dissolution Enhancement Using Different ...
Publisher: Lap Lambert Academic Publishing
Publication Date: 2013
Binding: Paperback
Condition: Brand New