Dislocation and Degradation of Proteins from the Endoplasmic Reticulum
Language: English
Published by Springer Berlin Heidelberg, 2014
Series: Book 13 of 322 - Current Topics in Microbiology and Immunology
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 148.98
Quantity: 1 available
Add to basketItem description from seller
Druck auf Anfrage Neuware - Printed after ordering - The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein's genesis and terminal fate in the endoplasmic reticulum (ER). This area is of immediate medical relevance and has blossomed, to no small extent, because of the study of molecules central to the function of the immune system [immunogl- ulins, T cell receptors, major histocompatibility complex (MHC)-encoded products]. Similarly, the clever strategies used by bacteria or viruses to gain a foothold in the host and ensure their continued survival have uncovered altogether new cell biological principles. It is therefore tting that a special volume be devoted to the interplay between pathways of protein degradation in the ER and a wide variety of pathogens. The concept of quality control emerged with the appreciation that, in the case of multimeric glycoproteins, any unpaired glycoprotein subunit had great dif culties leaving its site of synthesis-the ER-and was destroyed instead. Free immunoglobulin heavy chains were probably the earliest documented example of this kind, and were long known to cause pathology when their accumulation went unchecked. Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi cation of the ER as an important site where such quality control decisions were made. The T cell receptor for antigen, long considered the paradigm of this mode of degradation, led the way in these early explorations.…
Seller Inventory # 9783642421778
- Title
- Dislocation and Degradation of Proteins from the Endoplasmic Reticulum
- Author
- Marjolein Kikkert
- Publisher
- Springer Berlin Heidelberg
- Publication year
- 2014
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3642421776
- ISBN 13
- 9783642421778
- Item weight
- 295 grams
- Dimensions
- 235x155x11 mm
- Series
- Book 13 of 322: Current Topics in Microbiology and Immunology
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