Development of a New Computational Approach to the Prediction of Nucleic Acid
Language: English
Published by Forgotten Books, 2024
- Softcover
- New
Seller: Forgotten Books, London, United KingdomForgotten Books
AbeBooks seller since June 2, 2021
Condition: New
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Print on Demand. This book presents the development of a novel computational approach to predict the three-dimensional structure of deoxyribose nucleic acids by potential energy methods. The significance of the approach lies in its ability to incorporate experimental data known from crystal structures of small molecules, and to make reliable predictions of structures of larger biological systems. The author's strategy consists of representing the molecular conformation in cartesian coordinate space with the full set of degrees of freedom associated with the molecular conformation, allowing all bond lengths and bond angles as well as dihedral angles to vary. All the interactions other than the non-bonded terms are represented by polynomials of the coordinate variables. This formulation allows direct differentiation with respect to the cartesian variables and facilitates manipulation and differentiation of the energy terms. The text examines in detail the influence of different potential energy sets on the structures obtained and on the C3' endo/C2' endo energy difference. The author explores the contribution of each energy potential from Energy versus P (the pseudorotation parameter) profiles. These curves also provide an opportunity to investigate the approximation made in the pseudorotation description. The concluding insights of this book are significant because they provide a deeper understanding of the correlation between conformation and biological function, offering a valuable tool for revealing details of molecular conformation, motion, and associated biological functions. This book is a reproduction of an important historical work, digitally reconstructed using state-of-the-art technology to preserve the original format. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in the book.…
Seller Inventory # 9781333716363_0
- Title
- Development of a New Computational Approach to the Prediction of Nucleic Acid
- Author
- Tamar Schlick, Charles Peskin
- Publisher
- Forgotten Books
- Publication year
- 2024
- Condition
- New
- Book Type
- print-on-demand item
- Binding
- Paperback
- Language
- English
- ISBN 10
- 1333716362
- ISBN 13
- 9781333716363
- Seller catalogs
- Calculus
In the next section, we describe the fundamental issues of computational approaches while explaining the directions we have chosen. Section 3 discusses the methods: geometric construction, energv formulation and parameterization. And organization for minimization. In Section 4. We examine in detail the in fluence of different potential energy sets on the structures obtained and on the C3' - endo/c2' - endo energv difference. In particular. We can study the contribution of each energy potential from Energv vs. P (the pseudorotation parameter) profiles. These curves also provide an opportunity to investigate the approximation made in the'pséudorojtation description.
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Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com
This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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Forgotten Books publishes hundreds of thousands of rare and classic books.
This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
This text has been digitally restored from a historical edition. Some errors may persist, however we consider it worth publishing due to the work's historical value.
The digital edition of all books may be viewed before purchase if you request a sample.
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