Development of Micro-emulsion based formulation of Nifedipine

Language: English

Published by LAP LAMBERT Academic Publishing Apr 2023, 2023

6206159205 / 9786206159209

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -The aim of project work was to develop Self micro-emulsified drug delivery system of nifedipine to increase the solubility in gastric environment to enhance the bioavailability. For suitable development of SMEDDS of nifedipine was studied to know the solubility in various oil, solvent and co-solvent to select the suitable oil and various components for SMEDDS formulation. Nifedipine showed the solubility in sesame oil, tween 80 and propylene glycol. solvent and co-solvent were mixed in various ratios to find the effective ratio for microemulsion formation. At least 26 were developed and only four shows the property of microemulsion which was observed by visual assessment in distilled water.Various formulations were developed and upon subjection of these trials, only trial F14 and F17 remain monophasic i.e. phase separation do not occur. Among these two trial only trial F14 show the characteristic of microemulsion i.e. showed >95 % transmittance. In that formulation oil, surfactant and co-surfactant was 4:4:2 respectively.At least three trials are carried to find the suitable ratio of various excipient in the preparation SMEDDS of nifedipine. 88 pp. Englisch. …

Seller Inventory # 9786206159209

Title
Development of Micro-emulsion based formulation of Nifedipine
Author
Popin Kumar
Publisher
LAP LAMBERT Academic Publishing Apr 2023
Publication year
2023
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6206159205
ISBN 13
9786206159209
Item weight
149 grams
Dimensions
220x150x6 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany