Development of Isoniazid Loaded Silk Fibroin Microsphere

Narinder Singh

ISBN 10: 333005767X / ISBN 13: 9783330057678

Published by LAP LAMBERT Academic Publishing Mär 2017, 2017

About this Item

Neuware -Current experimental investigation is dedicated to prepare microspheres with small size and good Sphericity by Phase Separation method using Isoniazid (INH) as model drug. Silk fibroin has unique intrinsic qualities like biodegradability, biocompatibility or release properties and their tunable drug loading capacity. The delivery loading proficiency of the drug molecules in silk spheres be contingent on their charge and hydrophobicity or subsequent in altered drug release profile. In the present work Isoniazid loaded silk fibroin microsphere was prepared by using phase Separation method. Microsphere was evaluated by Ultraviolet-visible spectroscopy, Fourier Transform Infrared spectroscopy, Entrapment efficiency, Scanning electron microscopy Studies. Scanning electron microscopy studies revealed that Isoniazid Loaded Silk Fibroin Microspheres were spherical. Experimental report disclosed a new aqueous based formulation method for silk spheres with controllable shape or size and sphere. Isoniazid loaded silk microspheres may act as ideal nanoformulation with elaborated studies.Books on Demand GmbH, Überseering 33, 22297 Hamburg 92 pp. Englisch.

Seller Inventory # 9783330057678

Bibliographic Details

• Title: Development of Isoniazid Loaded Silk Fibroin Microsphere
• Publisher: LAP LAMBERT Academic Publishing Mär 2017
• Publication Date: 2017
• Language: English
• ISBN 10: 333005767X
• ISBN 13: 9783330057678
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 6D millimeters 220 millimeters width by 150 millimeters height by 6 millimeters depth
• Weight: 155 grams

About this title

Synopsis

Current experimental investigation is dedicated to prepare microspheres with small size and good Sphericity by Phase Separation method using Isoniazid (INH) as model drug. Silk fibroin has unique intrinsic qualities like biodegradability, biocompatibility or release properties and their tunable drug loading capacity. The delivery loading proficiency of the drug molecules in silk spheres be contingent on their charge and hydrophobicity or subsequent in altered drug release profile. In the present work Isoniazid loaded silk fibroin microsphere was prepared by using phase Separation method. Microsphere was evaluated by Ultraviolet-visible spectroscopy, Fourier Transform Infrared spectroscopy, Entrapment efficiency, Scanning electron microscopy Studies. Scanning electron microscopy studies revealed that Isoniazid Loaded Silk Fibroin Microspheres were spherical. Experimental report disclosed a new aqueous based formulation method for silk spheres with controllable shape or size and sphere. Isoniazid loaded silk microspheres may act as ideal nanoformulation with elaborated studies.

About the Author

Narinder Singh (M.Pharma) (Pharmaceutics) from CT Institute of Pharmaceutical Sciences, Jalandhar, Punjab with first division & (B.Pharma) from Rayat-Bahra Institute of Pharmacy, Hoshiarpur, Punjab. Author has presence in the pharmaceutics research.Have authored research/review publications.Author has grateful to Parents & Dr. Surya Prakash Gautam.