Detection of Translocation t(11;18) by FISH in GIT MALT Lymphomas : Pathological and Immunohistochemical Study of Gastrointestinal Lymphomas

Language: English

Published by LAP Lambert Academic Publishing, 2012

3848440776 / 9783848440771

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nach der Bestellung gedruckt Neuware - Printed after ordering - Lymphoma is a neoplasm of the immune system cells and their precursors. Despite their common origin from bone marrow, these tumors exhibit a wide range of immunological and genetic characteristics, which reflect the diversity of their normal counterpart cells. Lymphoid malignancies arise from both B and T cell compartments of the immune system. The cytogenetic analysis of lymphomas is hampered by the low yield and poor quality of metaphase spreads. More recently however, the application of techniques such as FISH and PCR, for which culturing of tumor cells is not a pre-requisite, has improved the characterization of lymphomas at the genetic level. Chromosomal translocations have an established role in diagnosis, prognosis, and prediction of response to treatment in haematologic and lymphoid malignancies. FISH, the assay of choice for localization of specific nucleic acids sequences in native context, is a 20-year-old technology that has developed continuously. Over its maturation, various methodologies and modifications have been introduced to optimize the detection of DNA and RNA.

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Title
Detection of Translocation t(11;18) by FISH in GIT MALT Lymphomas : Pathological and Immunohistochemical Study of Gastrointestinal Lymphomas
Author
Iman Mamdouh Talaat
Publisher
LAP Lambert Academic Publishing
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3848440776
ISBN 13
9783848440771
Item weight
320 grams
Dimensions
22.00x15.00x1.20 cm

AHA-BUCH GmbH

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